Model family

Profluent-E1

Profluent-E1 is a model family from Profluent1 2 3, with 3 assessed releases in this catalog. Licenses and availability are recorded for each release, not for the family; its releases use the Profluent-E1 Clickthrough License Agreement.

Profluent-E1 is a family of protein encoder language models from Profluent, announced in November 2025 in 150M, 300M, and 600M parameter sizes. The models can take homologous sequences alongside a query sequence (retrieval augmentation) or run on a single sequence, and Profluent presents them as drop-in replacements for ESM-family encoders.5 1 4Fact reviewed Oct 1, 2026

Last reviewedOct 1, 2026Entry updated Oct 1, 2026Documented release Nov 2025

Releases assessed

Each release is assessed on its own. This family has no family-wide openness label.

Releases in the Profluent-E1 family
Release	Weights	Tier (USASI rubric v0.2)	License	Released
Profluent-E1 150M (E1-150m)	Weights: Public	Model-disclosure tier (USASI rubric v0.2): Open-weight	Profluent-E1 Clickthrough License Agreement, Apache-2.0	Nov 13, 2025
Profluent-E1 300M (E1-300m)	Weights: Public	Model-disclosure tier (USASI rubric v0.2): Open-weight	Profluent-E1 Clickthrough License Agreement, Apache-2.0	Nov 13, 2025
Profluent-E1 600M (E1-600m)	Weights: Public	Model-disclosure tier (USASI rubric v0.2): Open-weight	Profluent-E1 Clickthrough License Agreement, Apache-2.0	Nov 13, 2025

What it is useful for

Profluent describes uses in protein fitness prediction, structure prediction, and representation learning; the repository includes notebooks for embeddings, zero-shot fitness prediction of substitution mutants, and in-silico site-saturation mutagenesis.5 1Fact reviewed Oct 1, 2026

Organization context

Profluent

U.S. eligibility

Project eligibility rests on documented governing or maintaining entities, not on contributors.

Eligible · basis: U.S.-governed project

Profluent-E1 is published by Profluent in its GitHub and Hugging Face organizations, and its license and notice name Profluent Bio Inc. as licensor and copyright holder. Profluent's website terms give an Emeryville, California notice address.1 2 3 6

Assessed Oct 1, 2026

Sources

1.
Profluent-AI/E1 README (external site: raw.githubusercontent.com)
Profluent · Repository · accessed Oct 1, 2026 · evidence reviewed Oct 1, 2026
2.
Profluent-E1 Clickthrough License Agreement (Profluent-AI/E1 LICENSE) (external site: raw.githubusercontent.com)
Profluent Bio Inc. · License · accessed Oct 1, 2026 · evidence reviewed Oct 1, 2026
3.
Profluent-E1 Notice File (Profluent-AI/E1 NOTICE) (external site: raw.githubusercontent.com)
Profluent Bio Inc. · License · accessed Oct 1, 2026 · evidence reviewed Oct 1, 2026
4.
Profluent-Bio models on Hugging Face (model list API) (external site: huggingface.co)
Hugging Face · Other · accessed Oct 1, 2026 · evidence reviewed Oct 1, 2026
5.
Introducing Profluent-E1 (Profluent showcase) (external site: profluent.bio)
Profluent · Announcement · published Nov 13, 2025 · accessed Oct 1, 2026 · evidence reviewed Oct 1, 2026
6.
Profluent Terms of Service (external site: profluent.bio)
Profluent Bio Inc. · Official page · published Jan 1, 2025 · accessed Oct 1, 2026 · evidence reviewed Oct 1, 2026

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APA style

USASI. (2026, October 1). Profluent-E1. United States of America Superintelligence. https://unitedstatesofamericasuperintelligence.com/open/profluent-e1/

BibTeX

@misc{usasi_profluent_e1,
  author = {{USASI}},
  title = {Profluent-E1},
  year = {2026},
  month = oct,
  howpublished = {\url{https://unitedstatesofamericasuperintelligence.com/open/profluent-e1/}},
  note = {United States of America Superintelligence. Last updated 2026-10-01}
}

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Releases assessed

What it is useful for

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