AlphaProtein Novo
AlphaProtein Novo is a model family from Google DeepMind12, with 1 assessed release in this catalog. Licenses and availability are recorded for each release, not for the family; its releases use the AlphaProtein Novo Generator Model Parameters Terms of Use.
AlphaProtein Novo (AP Novo) is a Google DeepMind pipeline for designing new enzymes by scaffolding a structural catalytic motif. Its diffusion model, the AP Novo Generator, generates protein structures and sequences together, conditioned on the motif and ligand context; optional LigandMPNN sequence redesign, AlphaFold 3 structure prediction, and evaluation metrics complete the pipeline. The code and generator weights were published in October 2026 alongside a bioRxiv paper.123
- Repository: GitHub repository (alphaprotein-novo) (external site: github.com)
- License: AP Novo Generator Model Parameters Terms of Use (external site: github.com)
- Paper: Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo (bioRxiv) (external site: biorxiv.org)
Releases assessed
| Release | Weights | Tier (USASI rubric v0.2) | License | Released |
|---|---|---|---|---|
| AlphaProtein Novo Generator | Weights: Public | Model-disclosure tier (USASI rubric v0.2): Open-weight | AlphaProtein Novo Generator Model Parameters Terms of Use, Apache-2.0 | Oct 2026 |
What it is useful for
Organization context
In the news
Google DeepMind releases AlphaProtein Novo code and non-commercial generator weights
Google DeepMind published AlphaProtein Novo (AP Novo), a generative diffusion pipeline for de novo enzyme design through structural motif scaffolding, in a GitHub repository whose commits are dated from October 5, 2026. The README says the diffusion model co-generates protein structures and sequences conditioned on a catalytic motif and ligand context, and that it can be combined with LigandMPNN sequence redesign and AlphaFold 3 structure prediction; it points to a bioRxiv preprint describing the work. The software is licensed under Apache 2.0, but the generator weights are downloaded separately under terms of use, last modified October 5, 2026, that allow only non-commercial use by, or on behalf of, non-commercial organizations. USASI has not tested AlphaProtein Novo.
U.S. eligibility
Eligible · basis: U.S.-governed project
The repository is published in Google DeepMind's GitHub organization, its licensing section states copyright 2026 Google LLC, and the weights terms are an agreement with Google LLC (Google Ireland Limited for users in the EEA or Switzerland) under California law. See the google-deepmind organization record, which is assessed under U.S. control as part of Google.12
Sources
This listing is not an endorsement, a safety assessment, or a federal approval.
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Cite this page
APA style
USASI. (2026, October 11). AlphaProtein Novo. United States of America Superintelligence. https://unitedstatesofamericasuperintelligence.com/open/alphaprotein-novo/
BibTeX
@misc{usasi_alphaprotein_novo,
author = {{USASI}},
title = {AlphaProtein Novo},
year = {2026},
month = oct,
howpublished = {\url{https://unitedstatesofamericasuperintelligence.com/open/alphaprotein-novo/}},
note = {United States of America Superintelligence. Last updated 2026-10-11}
}The date is when this page was last updated. Add the date you read it if your style needs one.
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