Organization
Arc Institute
Arc Institute is a research lab and nonprofit research organization headquartered in Palo Alto, California12. This catalog lists 2 open model releases from Arc Institute, under licenses including the Apache License 2.0.
Documented roles: Research lab · Nonprofit research · Model developer
Arc Institute is an independent nonprofit research organization in Palo Alto, California, founded in 2021, that works in partnership with Stanford University, UC Berkeley, and UCSF. Its research spans experimental biology and computational models, including the Evo 2 DNA language model and virtual cell models.134
Using this organization’s offerings
The detailed audience, self-hosting, pricing, and restrictions review has not yet been completed. Consult the sourced product records below and the publisher’s current terms. Missing detail means unknown, not unavailable.
Key facts
- Ownership (separate from openness)
- Nonprofit
Recorded classification; fact-level ownership verification pending.
- Legal form
- Corporation recognized by the IRS as tax-exempt under Section 501(c)(3); the IRS extract classifies it as a hospital or medical research organization (170(b)(1)(A)(iii)).89
- Founded
- 20211
- Sectors
- Science, Research, Open models
What is and isn’t public
Products
No product records yet.
Cataloged artifacts
Notable documented facts
- Arc describes Evo 2 as developed by Arc and NVIDIA scientists together with collaborators at Stanford University, UCSF, UC Berkeley, Goodfire, and the University of Washington. It was released as a preprint in February 2025 and published in Nature on March 4, 2026.4
- Arc publishes Evo 2 code on GitHub and Evo 2 checkpoints and the OpenGenome2 training dataset on Hugging Face under the Apache License 2.0.576
In the news
Arc Institute releases PIE, a model for predicting cell responses to perturbations
On October 5, 2026, Arc Institute announced PIE ("Perturbation is Everything"), a model that predicts how cells respond to perturbations in contexts it has not seen by drawing on curated biological databases such as Cellosaurus, NCBI, Gene Ontology, DepMap, and PubChem. Arc says the full codebase, including training and evaluation pipelines, is on GitHub, with model checkpoints and processed datasets on Hugging Face and a bioRxiv preprint. The repository's README says PIE is released under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 license, which allows non-commercial use with attribution. USASI has not tested PIE.
What this catalog does not know
- Official careers page: not verified by this catalog.
- Products: none documented in this record.
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U.S. eligibility
Eligible · basis: U.S. nonprofit or lab
Arc Institute describes itself as an independent nonprofit research organization based in Palo Alto, California, and its contact page gives a Palo Alto address. The IRS exempt-organization extract for California lists Arc Research Institute at that address as a 501(c)(3) organization.128
Sources
This listing is not an endorsement or a federal approval.
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APA style
USASI. (2026, October 1). Arc Institute. United States of America Superintelligence. https://unitedstatesofamericasuperintelligence.com/companies/arc-institute/
BibTeX
@misc{usasi_arc_institute,
author = {{USASI}},
title = {Arc Institute},
year = {2026},
month = oct,
howpublished = {\url{https://unitedstatesofamericasuperintelligence.com/companies/arc-institute/}},
note = {United States of America Superintelligence. Last updated 2026-10-01}
}The date is when this page was last updated. Add the date you read it if your style needs one.
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