Organization

EvolutionaryScale

EvolutionaryScale is an AI model developer and research lab. This catalog lists 2 open model releases from EvolutionaryScale, under licenses including the MIT License.

Documented roles: Model developer · Research lab

EvolutionaryScale is a public benefit company that developed the ESM3 and ESM C (ESM Cambrian) protein language models. In November 2025 Biohub announced that the EvolutionaryScale team would join Biohub, and EvolutionaryScale's website now states that it is part of Biohub.4 5 1 6

Last reviewedSep 29, 2026Entry updated Oct 1, 2026

Status: On November 6, 2025, Biohub announced that the EvolutionaryScale team would join Biohub, a 501(c)(3) medical research organization supported by the Chan Zuckerberg Initiative. EvolutionaryScale's website now states that it is part of Biohub and that current ESM models, APIs, and related services are provided at biohub.ai under Biohub's terms. The ESM GitHub repository and the ESM model repositories on Hugging Face are now published under Biohub accounts. Its former terms of use are marked as no longer in effect and refer to the period before EvolutionaryScale joined Biohub. The sources reviewed describe the team joining Biohub (a law firm's client note calls it a strategic transaction with the Chan Zuckerberg Initiative) but do not document an acquisition of, or merger with, EvolutionaryScale, PBC, so no parent organization is linked.6 1 2 7 10 11

Using this organization’s offerings

Ownership, delivery, and openness answer different questions. Publicly traded does not mean open source; privately held does not mean closed.

The detailed audience, self-hosting, pricing, and restrictions review has not yet been completed. Consult the sourced product records below and the publisher’s current terms. Missing detail means unknown, not unavailable.

Key facts

Website: evolutionaryscale.ai (external site: evolutionaryscale.ai)
Legal name: EvolutionaryScale, PBC2 3
Ownership (separate from openness): Unit of another organization
Recorded classification; fact-level ownership verification pending.
Legal form: Public benefit corporation (EvolutionaryScale, PBC)2 4
Headquarters: Not documented
Founded: Unknown
Sectors: Science, Open models

What is and isn’t public

An evidence-based summary of what this catalog has documented. It is not a verdict on the organization as a whole.

The ESM3 open small model, the ESM C models, and the esm code are now published by Biohub under the MIT license; the ESM3 README lists the larger ESM3 models as accessed through Biohub, with only the small open model's weights on Hugging Face. See the ESM release records.7 9 8

Products

Documented products and how they are delivered. Each row links to the official page.

No product records yet.

Cataloged artifacts

Records in the Open Models & Tools directory that list this organization as a maintainer or publisher.

Model families (1)

ESM (EvolutionaryScale and Biohub protein models)Model family

Model releases (2)

ESM3 open small (esm3-sm-open-v1)Model releaseAvailability: PublicModel-disclosure tier (USASI rubric v0.2): Open-weight
ESMC 6B (ESM Cambrian)Model releaseAvailability: PublicModel-disclosure tier (USASI rubric v0.2): Open-weight

Notable documented facts

The EvolutionaryScale site hosts an EvolutionaryScale, PBC Community License Agreement covering the ESM-3 open model code and weights that limits use to non-commercial purposes. The current Biohub repository license and model card state the MIT license; the sources reviewed do not say when the terms changed.3 8 10
EvolutionaryScale's hosted Forge API has moved from forge.evolutionaryscale.ai to the Biohub Platform at biohub.ai; the esm SDK still uses Forge class names.7
EvolutionaryScale's former terms of use (effective January 15, 2025) gave a New York, New York address and New York governing law; the site marks those terms as no longer in effect.2

What this catalog does not know

Unknown means the sources reviewed for this record do not document it. It is not evidence that something does not exist.

Founding date: not documented in the sources reviewed.
Headquarters: not documented in the sources reviewed.
Official careers page: not verified by this catalog.
Products: none documented in this record.

Have a primary source? How to report a correction.

U.S. eligibility

How this record meets the catalog’s published eligibility policy.

Eligible · basis: Documented U.S. control

EvolutionaryScale's website states that it is now part of Biohub, and Biohub's announcement describes the EvolutionaryScale team joining Biohub. Chan Zuckerberg Biohub Inc is listed by the IRS as a 501(c)(3) organization in Redwood City, California. EvolutionaryScale, PBC's former terms of use (effective January 15, 2025) gave a New York address. The sources reviewed do not document the legal structure of the combination (for example, whether the PBC continues as a subsidiary); either way, the documented controlling and prior locations are in the United States.1 6 12 2

Assessed Sep 29, 2026

Eligibility policy

Sources

1.
EvolutionaryScale (home page) (external site: evolutionaryscale.ai)
EvolutionaryScale · Official page · accessed Sep 29, 2026
2.
Terms of Use (historical) | EvolutionaryScale (external site: evolutionaryscale.ai)
EvolutionaryScale · Official page · accessed Sep 29, 2026
3.
Community License Agreement | EvolutionaryScale (external site: evolutionaryscale.ai)
EvolutionaryScale · License · accessed Sep 29, 2026
4.
ESM3: Simulating 500 million years of evolution with a language model (external site: evolutionaryscale.ai)
EvolutionaryScale · Announcement · published Jun 25, 2024 · accessed Sep 29, 2026
5.
ESM Cambrian: Revealing the mysteries of proteins with unsupervised learning (external site: evolutionaryscale.ai)
EvolutionaryScale · Announcement · published Dec 4, 2024 · accessed Sep 29, 2026
6.
Biohub launches first large-scale scientific initiative combining frontier AI with frontier biology to cure or prevent disease (external site: biohub.org)
Biohub · Announcement · published Nov 6, 2025 · accessed Sep 29, 2026
7.
Biohub/esm (formerly evolutionaryscale/esm) (external site: github.com)
Biohub · Repository · accessed Sep 29, 2026
8.
Biohub/esm LICENSE.md (external site: raw.githubusercontent.com)
Chan Zuckerberg Biohub, Inc. · License · accessed Sep 29, 2026
9.
ESM3 README (Biohub/esm, _assets/ESM3_README.md) (external site: raw.githubusercontent.com)
Biohub · Documentation · accessed Sep 29, 2026
10.
biohub/esm3-sm-open-v1 model card (external site: huggingface.co)
Biohub · Model card · accessed Sep 29, 2026
11.
Gunderson Client EvolutionaryScale Team Joins Biohub in Strategic Transaction with Chan Zuckerberg Initiative (external site: gunder.com)
Gunderson Dettmer · News report · published Nov 6, 2025 · accessed Sep 29, 2026
12.
Exempt Organizations Business Master File Extract - California (eo_ca.csv) (external site: irs.gov)
Internal Revenue Service · Filing · accessed Sep 29, 2026
13.
Biohub careers page (linked as Join the team from evolutionaryscale.ai) (external site: biohub.org)
Biohub · Official page · accessed Oct 1, 2026 · evidence reviewed Oct 1, 2026

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APA style

USASI. (2026, October 1). EvolutionaryScale. United States of America Superintelligence. https://unitedstatesofamericasuperintelligence.com/companies/evolutionaryscale/

BibTeX

@misc{usasi_evolutionaryscale,
  author = {{USASI}},
  title = {EvolutionaryScale},
  year = {2026},
  month = oct,
  howpublished = {\url{https://unitedstatesofamericasuperintelligence.com/companies/evolutionaryscale/}},
  note = {United States of America Superintelligence. Last updated 2026-10-01}
}

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