ESM (EvolutionaryScale and Biohub protein models)
ESM (EvolutionaryScale and Biohub protein models) is a model family from Biohub (Chan Zuckerberg Biohub, Inc.)12 and EvolutionaryScale (original developer; now part of Biohub)567, with 2 assessed releases in this catalog. Licenses and availability are recorded for each release, not for the family; its releases use the MIT License.
Protein language models developed by EvolutionaryScale and, since its team joined Biohub in November 2025, released by Biohub. The line includes ESM3 (June 2024), a generative model that reasons over protein sequence, structure, and function, with a largest version of 98B parameters and a small open model; ESM C (ESM Cambrian, December 2024), representation models at 300M, 600M, and 6B parameters; and, from May 2026, ESMFold2 structure prediction models and sparse autoencoders built on ESM C.5631109
- Repository: GitHub repository (Biohub/esm) (external site: github.com)
- Model hub: ESM3 model family (Hugging Face) (external site: huggingface.co)
- Model hub: ESMC model family (Hugging Face) (external site: huggingface.co)
- Paper: ESM3 paper (Science, doi:10.1126/science.ads0018) (external site: science.org)
- Paper: ESMC and ESMFold2 preprint (bioRxiv) (external site: biorxiv.org)
On AI on Hugging Face: biohub/ESMFold2
Releases assessed
| Release | Weights | Tier (USASI rubric v0.2) | License | Released |
|---|---|---|---|---|
| ESM3 open small (esm3-sm-open-v1) | Weights: Public | Model-disclosure tier (USASI rubric v0.2): Open-weight | MIT | Jun 25, 2024 |
| ESMC 6B (ESM Cambrian) | Weights: Public | Model-disclosure tier (USASI rubric v0.2): Open-weight | MIT | May 2026 |
What it is useful for
Run and use notes
Organization context
Provenance and derivatives
In the news
Biohub's esm 3.4.0 package adds full support for ESMC and ESMFold2
Biohub published version 3.4.0 of its esm Python package on August 27, 2026. The release notes say it adds full support for ESMC and ESMFold2, a test suite for both, and a compatibility layer for the Hugging Face ports of ESMC and ESMFold2, while maintaining support for legacy model weights. Biohub's Hugging Face organization hosts ESMC-6B-hf, whose model card describes ESMC as a protein language model, says the ESMC 6B model has 6 billion parameters, and says Biohub is releasing source code and model weights for ESMC 6B, ESMFold2, and ESMC sparse autoencoders. The repository README says the models are available under the MIT license. USASI has not tested this release.
U.S. eligibility
Eligible · basis: U.S.-governed project
The models were developed by EvolutionaryScale, PBC, whose former terms of use (effective January 15, 2025) gave a New York address, and are now published by Biohub; the repository license names Chan Zuckerberg Biohub, Inc. as copyright holder. The IRS lists Chan Zuckerberg Biohub Inc in Redwood City, California as a 501(c)(3) organization. Eligibility of each release is assessed on the release record.82111
Sources
This listing is not an endorsement, a safety assessment, or a federal approval.
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APA style
USASI. (2026, September 29). ESM (EvolutionaryScale and Biohub protein models). United States of America Superintelligence. https://unitedstatesofamericasuperintelligence.com/open/esm/
BibTeX
@misc{usasi_esm,
author = {{USASI}},
title = {ESM (EvolutionaryScale and Biohub protein models)},
year = {2026},
month = sep,
howpublished = {\url{https://unitedstatesofamericasuperintelligence.com/open/esm/}},
note = {United States of America Superintelligence. Last updated 2026-09-29}
}The date is when this page was last updated. Add the date you read it if your style needs one.
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